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<p align="left" style="text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><a href="http://www.yindugo.com/yindugo-com/p/zhuanti_detail.php?id=78"><span style="color:#3498db;"><strong><span style="background-color:#f1c40f;">奥希替尼（Osimertinib）</span></strong></span></a><span style="color:#05073b">是一种用于治疗特定类型的非小细胞肺癌（NSCLC）的靶向药物。以下是奥希替尼的主要适应症：</span></span></span></span></span></span></p>

<ol>
	<li align="left" style="text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 36.0pt"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">具有T790M突变的非小细胞肺癌</span></span></span></b><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">：</span></span></span></span></span></span></span>

<ul style="list-style-type:circle">
		<li align="left" style="text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 72.0pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">奥西替尼主要用于治疗具有T790M突变的晚期或转移性非小细胞肺癌。这类突变是导致常规EGFR抑制剂失效的主要原因之一，占大约50%~60%的耐药病例。</span></span></span></span></span></span></span></li>
		<li align="left" style="margin-top:4.5pt; margin-right:0cm; margin-bottom:.0001pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 72.0pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">对于有T790M突变且接受二线治疗的患者，奥希替尼的客观缓解率约为70%，无进展生存期中位数约为10个月。</span></span></span></span></span></span></span></li>
	</ul>
	</li>
	<li align="left" style="text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 36.0pt"><span style="font-family:Calibri,"sans-serif""><b><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">携带敏感EGFR突变的非小细胞肺癌</span></span></span></b><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">：</span></span></span></span></span></span></span>
	<ul style="list-style-type:circle">
		<li align="left" style="text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 72.0pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">奥希替尼也可用于初治的携带敏感EGFR突变（如19号外显子缺失和L858R突变）的非小细胞肺癌患者。这些突变类型在东亚人群中的发生率较高，大约占所有非小细胞肺癌病例的10%~15%。</span></span></span></span></span></span></span></li>
		<li align="left" style="margin-top:4.5pt; margin-right:0cm; margin-bottom:.0001pt; text-align:left; margin:0cm 0cm 0.0001pt"><span style="font-size:10.5pt"><span style="background:#fdfdfe"><span style="tab-stops:list 72.0pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">对于初治EGFR突变患者，奥希替尼的无进展生存期中位数可延长至18个月左右。</span></span></span></span></span></span></span></li>
	</ul>
	</li>
</ol>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><strong><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b">奥希替尼可以通过印度代购</span></span></span></span></strong><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b"><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px">，但选择正规渠道至关重要，以确保药品的质量和安全性。</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

<p style="margin:0cm 0cm 0.0001pt; text-align:justify"><span style="font-size:10.5pt"><span style="font-family:Calibri,"sans-serif""><span style="font-size:12.0pt"><span style="background:#fdfdfe"><span style="font-family:"微软雅黑","sans-serif""><span style="color:#05073b"><span style="font-variant-ligatures:normal; text-align:start; -webkit-text-stroke-width:0px"><span style="font-variant-caps:normal"><span style="orphans:2"><span style="widows:2"><span style="text-decoration-thickness:initial"><span style="text-decoration-style:initial"><span style="text-decoration-color:initial"><span style="float:none"><span style="word-spacing:0px"><img alt="" src="../upload/6756ab7cee567343452485.jpg" style="width: 500px; height: 202px;" /></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p>

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